Catalog Number:
E1B1893Amount:
100ugPHYSICAL APPEARANCE: lyophilized solid (m.p.150-151°C)MOLECULAR FORMULA: C17H22N2O3 MOLECULAR WEIGHT: 302.4
Purity:
99% (HPLC)Solubility:
Soluble in DMSO, DMF and ethanolStorage/Stability:
Store solutions at -20°C for up to 1 year.Recommended Dilutions:
Potent, reversible inhibitor of histone deacetylase at nM concentrations, which thereby induces hyperacetylation of histones. Blocks cell cycle at G1. Induces reversion of ras transformed cells to normal morphology. Inhibits IL-2 gene expression in Jurkat cells (IC50 = 73 nM) and induces immunosuppression in a mouse model.References:
1. J. Taunton et al. Science 1996 272 3712. Y. Hoshikawa et al. Exp.Cell Res. 1994 214 1893. M. Futamura et al. Oncogene 1995 10 11194. I. Takahashi et al. Antibiotics 1996 49 453The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.Price:
50$Form of Antibody:
Trichostatin A[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideCAS NO: 58880-19-6enogene的PTEN(Phospho-Ser380)抗体PDF
目录编号:E011009-1
量:50微克/ 50微升
抗体形式:磷酸盐缓冲盐水(不含Mg2 +和Ca2 +),pH 7.4、150mM NaCl,0.02%叠氮化钠和50%甘油的兔IgG。
储存/稳定性:-20℃/ 1年保存
免疫原产生抗人丝氨酸380(RY-SP-DT)磷酸化位点周围人PTEN合成的磷酸肽的抗血清。
纯化:使用表位特异性磷酸肽通过亲和层析从兔抗血清中亲和纯化抗体。使用对应于磷酸化位点的非磷酸肽,通过色谱法除去针对非磷酸肽的抗体。
特异性/敏感性:PTEN(phospho-Ser380)抗体仅在丝氨酸380磷酸化时才检测PTEN的内源性水平。
反应性:人,小鼠,大鼠
应用范围:IHC:1:50〜1:100